Perspectives for the reconstruction of 3D chromatin conformation using single cell Hi-C data

Construction of chromosomes 3D models based on single cell Hi-C data constitute an important challenge. We present a reconstruction approach, DPDchrom, that incorporates basic knowledge whether the reconstructed conformation should be coil-like or globular and spring relaxation at contact sites. In...

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Detalles Bibliográficos
Autores principales: Kos, Pavel I., Galitsyna, Aleksandra A., Ulianov, Sergey V., Gelfand, Mikhail S., Razin, Sergey V., Chertovich, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601426/
https://www.ncbi.nlm.nih.gov/pubmed/34793453
http://dx.doi.org/10.1371/journal.pcbi.1009546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601426/
https://www.ncbi.nlm.nih.gov/pubmed/34793453
http://dx.doi.org/10.1371/journal.pcbi.1009546

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