The P. falciparum CSP repeat region contains three distinct epitopes required for protection by antibodies in vivo

Rare and potent monoclonal antibodies (mAbs) against the Plasmodium falciparum (Pf) circumsporozoite protein (CSP) on infective sporozoites (SPZ) preferentially bind the PfCSP junctional tetrapeptide NPDP or NVDP minor repeats while cross-reacting with NANP central repeats in vitro. The extent to wh...

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Detalles Bibliográficos
Autores principales: Flores-Garcia, Yevel, Wang, Lawrence T., Park, Minah, Asady, Beejan, Idris, Azza H., Kisalu, Neville K., Muñoz, Christian, Pereira, Lais S., Francica, Joseph R., Seder, Robert A., Zavala, Fidel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601602/
https://www.ncbi.nlm.nih.gov/pubmed/34748617
http://dx.doi.org/10.1371/journal.ppat.1010042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601602/
https://www.ncbi.nlm.nih.gov/pubmed/34748617
http://dx.doi.org/10.1371/journal.ppat.1010042

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