The Impact of the HydroxyMethylCytosine epigenetic signature on DNA structure and function

We present a comprehensive, experimental and theoretical study of the impact of 5-hydroxymethylation of DNA cytosine. Using molecular dynamics, biophysical experiments and NMR spectroscopy, we found that Ten-Eleven translocation (TET) dioxygenases generate an epigenetic variant with structural and p...

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Detalles Bibliográficos
Autores principales: Battistini, Federica, Dans, Pablo D., Terrazas, Montserrat, Castellazzi, Chiara L., Portella, Guillem, Labrador, Mireia, Villegas, Núria, Brun-Heath, Isabelle, González, Carlos, Orozco, Modesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601608/
https://www.ncbi.nlm.nih.gov/pubmed/34748533
http://dx.doi.org/10.1371/journal.pcbi.1009547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601608/
https://www.ncbi.nlm.nih.gov/pubmed/34748533
http://dx.doi.org/10.1371/journal.pcbi.1009547

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