NAMPT-derived NAD(+) fuels PARP1 to promote skin inflammation through parthanatos cell death

Several studies have revealed a correlation between chronic inflammation and nicotinamide adenine dinucleotide (NAD(+)) metabolism, but the precise mechanism involved is unknown. Here, we report that the genetic and pharmacological inhibition of nicotinamide phosphoribosyltransferase (Nampt), the ra...

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Detalles Bibliográficos
Autores principales: Martínez-Morcillo, Francisco J., Cantón-Sandoval, Joaquín, Martínez-Navarro, Francisco J., Cabas, Isabel, Martínez-Vicente, Idoya, Armistead, Joy, Hatzold, Julia, López-Muñoz, Azucena, Martínez-Menchón, Teresa, Corbalán-Vélez, Raúl, Lacal, Jesús, Hammerschmidt, Matthias, García-Borrón, José C., García-Ayala, Alfonsa, Cayuela, María L., Pérez-Oliva, Ana B., García-Moreno, Diana, Mulero, Victoriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601609/
https://www.ncbi.nlm.nih.gov/pubmed/34748530
http://dx.doi.org/10.1371/journal.pbio.3001455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601609/
https://www.ncbi.nlm.nih.gov/pubmed/34748530
http://dx.doi.org/10.1371/journal.pbio.3001455

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