Cargando…

NAMPT-derived NAD(+) fuels PARP1 to promote skin inflammation through parthanatos cell death

Several studies have revealed a correlation between chronic inflammation and nicotinamide adenine dinucleotide (NAD(+)) metabolism, but the precise mechanism involved is unknown. Here, we report that the genetic and pharmacological inhibition of nicotinamide phosphoribosyltransferase (Nampt), the ra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martínez-Morcillo, Francisco J., Cantón-Sandoval, Joaquín, Martínez-Navarro, Francisco J., Cabas, Isabel, Martínez-Vicente, Idoya, Armistead, Joy, Hatzold, Julia, López-Muñoz, Azucena, Martínez-Menchón, Teresa, Corbalán-Vélez, Raúl, Lacal, Jesús, Hammerschmidt, Matthias, García-Borrón, José C., García-Ayala, Alfonsa, Cayuela, María L., Pérez-Oliva, Ana B., García-Moreno, Diana, Mulero, Victoriano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601609/ https://www.ncbi.nlm.nih.gov/pubmed/34748530 http://dx.doi.org/10.1371/journal.pbio.3001455

Ejemplares similares

NAMPT and PARylation Are Involved in the Pathogenesis of Atopic Dermatitis
por: Arroyo, Ana B., et al.
Publicado: (2023)

The Effect of 17α-Ethynylestradiol on Steroidogenesis and Gonadal Cytokine Gene Expression Is Related to the Reproductive Stage in Marine Hermaphrodite Fish
por: Cabas, Isabel, et al.
Publicado: (2013)

Impact of Comorbidities of Patients with Psoriasis on Phototherapy Responses
por: Fatás-Lalana, Belén, et al.
Publicado: (2022)

Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern
por: Tyrkalska, Sylwia D., et al.
Publicado: (2022)

Estrogens Promote the Production of Natural Neutralizing Antibodies in Fish through G Protein-Coupled Estrogen Receptor 1
por: Rodenas, María C., et al.
Publicado: (2017)

G Protein-Coupled Estrogen Receptor 1 Regulates Human Neutrophil Functions
por: Rodenas, M. Carmen, et al.
Publicado: (2017)

Boosting NAD(+) with a small molecule that activates NAMPT
por: Gardell, Stephen J., et al.
Publicado: (2019)

Premature aging in telomerase-deficient zebrafish
por: Anchelin, Monique, et al.
Publicado: (2013)

Flow cytometry based techniques to study testicular acidophilic granulocytes from the protandrous fish gilthead seabream (Sparus aurata L.)
por: Chaves-Pozo, Elena, et al.
Publicado: (2004)

Senescence-Independent Anti-Inflammatory Activity of the Senolytic Drugs Dasatinib, Navitoclax, and Venetoclax in Zebrafish Models of Chronic Inflammation
por: Hernández-Silva, David, et al.
Publicado: (2022)

NAMPT-Mediated Salvage Synthesis of NAD(+) Controls Morphofunctional Changes of Macrophages
por: Venter, Gerda, et al.
Publicado: (2014)

AMPK phosphorylates NAMPT to regulate NAD(+) homeostasis under ionizing radiation
por: Liao, Xiaoyu, et al.
Publicado: (2022)

Potential Therapeutic Effects of NAMPT-Mediated NAD Biosynthesis in Depression In Vivo
por: Wang, Jue, et al.
Publicado: (2022)

Testicular involution prior to sex change in gilthead seabream is characterized by a decrease in DMRT1 gene expression and by massive leukocyte infiltration
por: Liarte, Sergio, et al.
Publicado: (2007)

NAMPT-mediated NAD(+) biosynthesis is indispensable for adipose tissue plasticity and development of obesity
por: Nielsen, Karen Nørgaard, et al.
Publicado: (2018)

NAPRT, but Not NAMPT, Provides Additional Support for NAD Synthesis in Esophageal Precancerous Lesions
por: Wang, Niannian, et al.
Publicado: (2022)

The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish
por: Tyrkalska, Sylwia D., et al.
Publicado: (2023)

Telomerase reverse transcriptase activates transcription of miR500A to inhibit Hedgehog signalling and promote cell invasiveness
por: Bernabé‐García, Manuel, et al.
Publicado: (2021)

Effects of Sex Steroids on Fish Leukocytes
por: Chaves-Pozo, Elena, et al.
Publicado: (2018)

Evaluation of an autonomous smart system for optimal management of fertigation with variable sources of irrigation water
por: Imbernón-Mulero, Alberto, et al.
Publicado: (2023)

Targeting Parthanatos in Ischemic Stroke
por: Koehler, Raymond C., et al.
Publicado: (2021)

Exercise increases the release of NAMPT in extracellular vesicles and alters NAD (+) activity in recipient cells
por: Chong, Mee Chee, et al.
Publicado: (2022)

NAMPT-dependent NAD(+) biosynthesis controls circadian metabolism in a tissue-specific manner
por: Basse, Astrid L., et al.
Publicado: (2023)

Telomerase RNA-based aptamers restore defective myelopoiesis in congenital neutropenic syndromes
por: Martínez-Balsalobre, Elena, et al.
Publicado: (2023)

Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity
por: Lynn, Heather, et al.
Publicado: (2023)

The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD(+)/SIRT1 in mammalian aging and longevity control
por: Imai, Shin-ichiro
Publicado: (2016)

Catastrophic NAD(+) Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE
por: Bruzzone, Santina, et al.
Publicado: (2009)

Dietary proanthocyanidins modulate BMAL1 acetylation, Nampt expression and NAD levels in rat liver
por: Ribas-Latre, Aleix, et al.
Publicado: (2015)

Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD(+) protects the heart against pressure overload
por: Yano, Masamichi, et al.
Publicado: (2015)

Loss of NAMPT in aging retinal pigment epithelium reduces NAD(+) availability and promotes cellular senescence
por: Jadeja, Ravirajsinh N., et al.
Publicado: (2018)

NAMPT reduction‐induced NAD(+) insufficiency contributes to the compromised oocyte quality from obese mice
por: Wang, Hengjie, et al.
Publicado: (2021)

NAD/NAMPT and mTOR Pathways in Melanoma: Drivers of Drug Resistance and Prospective Therapeutic Targets
por: Indini, Alice, et al.
Publicado: (2022)

TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response
por: Espín-Palazón, Raquel, et al.
Publicado: (2016)

Application of the dual-luciferase reporter assay to the analysis of promoter activity in Zebrafish embryos
por: Alcaraz-Pérez, Francisca, et al.
Publicado: (2008)

Mahogunin Ring Finger 1 Is Required for Genomic Stability and Modulates the Malignant Phenotype of Melanoma Cells
por: Martínez-Vicente, Idoya, et al.
Publicado: (2020)

NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer
por: Li, Xiao-qin, et al.
Publicado: (2019)

Nicotine rebalances NAD(+) homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity
por: Yang, Liang, et al.
Publicado: (2023)

Ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression
por: Zhuang, Yongxian, et al.
Publicado: (2023)

An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages
por: López-Muñoz, Azucena, et al.
Publicado: (2018)

Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase
por: Armistead, Joy, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_isob4nvls7du92213f1op2m8qk