Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts

ES-62 is the major secreted protein of the parasitic filarial nematode, Acanthocheilonema viteae. The molecule exists as a large tetramer (MW, ~240kD), which possesses immunomodulatory properties by virtue of multiple phosphorylcholine (PC) moieties attached to N-type glycans. By suppressing inflamm...

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Detalles Bibliográficos
Autores principales: Corbet, Marlene, Pineda, Miguel A., Yang, Kun, Tarafdar, Anuradha, McGrath, Sarah, Nakagawa, Rinako, Lumb, Felicity E., Suckling, Colin J., Harnett, William, Harnett, Margaret M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601611/
https://www.ncbi.nlm.nih.gov/pubmed/34748611
http://dx.doi.org/10.1371/journal.ppat.1010069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601611/
https://www.ncbi.nlm.nih.gov/pubmed/34748611
http://dx.doi.org/10.1371/journal.ppat.1010069

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