Changes in MDA5 and TLR3 Sensing of the Same Diabetogenic Virus Result in Different Autoimmune Disease Outcomes

Seemingly redundant in function, melanoma differentiation-associated protein 5 (MDA5) and toll-like receptor- 3 (TLR3) both sense RNA viruses and induce type I interferon (IFN-I). Herein, we demonstrate that changes in sensing of the same virus by MDA5 and TLR3 can lead to distinct signatures of IFN...

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Detalles Bibliográficos
Autores principales: Lincez, Pamela J., Shanina, Iryna, Horwitz, Marc S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602094/
https://www.ncbi.nlm.nih.gov/pubmed/34804036
http://dx.doi.org/10.3389/fimmu.2021.751341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602094/
https://www.ncbi.nlm.nih.gov/pubmed/34804036
http://dx.doi.org/10.3389/fimmu.2021.751341

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