The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality

PURPOSE: Organic Anion Transporting Polypeptide 1B1 (OATP1B1) mediates hepatic influx and clearance of many drugs, including statins. The SLCO1B1 gene is highly polymorphic and its function-impairing variants can predispose patients to adverse effects. The effects of rare genetic variants of SLCO1B1...

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Detalles Bibliográficos
Autores principales: Kiander, Wilma, Vellonen, Kati-Sisko, Malinen, Melina M., Gynther, Mikko, Hagström, Marja, Bhattacharya, Madhushree, Auriola, Seppo, Koenderink, Jan B., Kidron, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602229/
https://www.ncbi.nlm.nih.gov/pubmed/34647232
http://dx.doi.org/10.1007/s11095-021-03107-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602229/
https://www.ncbi.nlm.nih.gov/pubmed/34647232
http://dx.doi.org/10.1007/s11095-021-03107-8

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