Genetic fusions favor tumorigenesis through degron loss in oncogenes

Chromosomal rearrangements can generate genetic fusions composed of two distinct gene sequences, many of which have been implicated in tumorigenesis and progression. Our study proposes a model whereby oncogenic gene fusions frequently alter the protein stability of the resulting fusion products, via...

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Detalles Bibliográficos
Autores principales: Liu, Jing, Tokheim, Collin, Lee, Jonathan D., Gan, Wenjian, North, Brian J., Liu, X. Shirley, Pandolfi, Pier Paolo, Wei, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602260/
https://www.ncbi.nlm.nih.gov/pubmed/34795215
http://dx.doi.org/10.1038/s41467-021-26871-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602260/
https://www.ncbi.nlm.nih.gov/pubmed/34795215
http://dx.doi.org/10.1038/s41467-021-26871-y

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