Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease

Pathogenic autoantibodies contribute to tissue damage and clinical decline in autoimmune disease. Follicular T cells are central regulators of germinal centers, although their contribution to autoantibody-mediated disease remains unclear. Here we perform single cell RNA and T cell receptor (TCR) seq...

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Detalles Bibliográficos
Autores principales: Akama-Garren, Elliot H., van den Broek, Theo, Simoni, Lea, Castrillon, Carlos, van der Poel, Cees E., Carroll, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602266/
https://www.ncbi.nlm.nih.gov/pubmed/34795279
http://dx.doi.org/10.1038/s41467-021-27035-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602266/
https://www.ncbi.nlm.nih.gov/pubmed/34795279
http://dx.doi.org/10.1038/s41467-021-27035-8

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