Cargando…

Safety and efficacy of thalidomide in patients with transfusion-dependent β-thalassemia: a randomized clinical trial

Thalidomide induces γ-globin expression in erythroid progenitor cells, but its efficacy on patients with transfusion-dependent β-thalassemia (TDT) remains unclear. In this phase 2, multi-center, randomized, double-blind clinical trial, we aimed to determine the safety and efficacy of thalidomide in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jiang-Ming, Zhu, Wei-Jian, Liu, Jie, Wang, Gui-Zhen, Chen, Xiao-Qin, Tan, Yun, Xu, Wei-Wei, Qu, Li-Wei, Li, Jin-Yan, Yang, Huan-Ju, Huang, Lan, Cai, Ning, Wang, Wei-Da, Huang, Ken, Xu, Jian-Quan, Li, Guo-Hui, He, Sheng, Luo, Tian-Ying, Huang, Yi, Liu, Song-Hua, Wu, Wen-Qiang, Lu, Qi-Yang, Zhou, Mei-Guang, Chen, Shu-Ying, Li, Rong-Lan, Hu, Mei-Ling, Huang, Ying, Wei, Jin-Hua, Li, Jun-Min, Chen, Sai-Juan, Zhou, Guang-Biao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602273/ https://www.ncbi.nlm.nih.gov/pubmed/34795208 http://dx.doi.org/10.1038/s41392-021-00811-0

Ejemplares similares

Thalidomide for the Treatment of Thrombocytopenia and Hypersplenism in Patients With Cirrhosis or Thalassemia
por: Chen, Yaocheng, et al.
Publicado: (2020)

Efficacy of Thalidomide Treatment in Children With Transfusion Dependent β-Thalassemia: A Retrospective Clinical Study
por: Li, Xinyu, et al.
Publicado: (2021)

Magnetic Resonance Imaging Quantification of the Liver Iron Burden and Volume Changes Following Treatment With Thalidomide in Patients With Transfusion-Dependent ß-Thalassemia
por: Che, Jinlian, et al.
Publicado: (2022)

Thalidomide for Patients with β-Thalassemia: A Multicenter Experience
por: Yang, Kun, et al.
Publicado: (2020)

Investigating the Efficacy and Safety of Thalidomide for Treating Patients With ß-Thalassemia: A Meta-Analysis
por: Lu, Yanfei, et al.
Publicado: (2022)

Challenges in transfusion and the role of Thalidomide in E‐β‐Thalassemia—A case report
por: Javed, Rizwan, et al.
Publicado: (2020)

Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis
por: Huang, Yumei, et al.
Publicado: (2019)

Genomic variations in paired normal controls for lung adenocarcinomas
por: Qu, Li-Wei, et al.
Publicado: (2017)

Iron overload status in patients with non-transfusion-dependent thalassemia in China
por: Huang, Yumei, et al.
Publicado: (2022)

A comparative dosimetric study for treating left-sided breast cancer for small breast size using five different radiotherapy techniques: conventional tangential field, filed-in-filed, Tangential-IMRT, Multi-beam IMRT and VMAT
por: Jin, Guang-Hua, et al.
Publicado: (2013)

HCCS1-armed, quadruple-regulated oncolytic adenovirus specific for liver cancer as a cancer targeting gene-viro-therapy strategy
por: Xu, Hai-Neng, et al.
Publicado: (2011)

The gene spectrum of thalassemia in Yangjiang of western Guangdong Province
por: Liang, Hong-Feng, et al.
Publicado: (2023)

Thalidomide for Recurrence of Symptoms following HIV-Associated Cryptococcal Meningitis
por: Qi, Tangkai, et al.
Publicado: (2023)

The Correlation Between Timing of Surgery and the Need for RBC Transfusions in the Geriatric Intertrochanteric Fracture Population
por: Yang, Yun-fa, et al.
Publicado: (2021)

Use of esophageal balloon pressure-volume curve analysis to determine esophageal wall elastance and calibrate raw esophageal pressure: a bench experiment and clinical study
por: Sun, Xiu-Mei, et al.
Publicado: (2018)

Early Kinetics of Procalcitonin in Predicting Surgical Outcomes in Type A Aortic Dissection Patients
por: Liu, Hua, et al.
Publicado: (2017)

Establishment and Evaluation of a Novel Method Based on Loop-Mediated Isothermal Amplification for the Rapid Diagnosis of Thalassemia Genes
por: Wang, Wei-hua, et al.
Publicado: (2020)

P1133: CHIDAMIDE PLUS PREDNISONE, CYCLOPHOSPHAMIDE, AND THALIDOMIDE (CPCT) FOR RELAPSED OR REFRACTORY PERIPHERAL T-CELL LYMPHOMA: A MULTICENTER PHASE II TRIAL
por: Liang, Jinhua, et al.
Publicado: (2023)

Risk factors of perioperative blood transfusion in elderly patients with femoral intertrochanteric fracture
por: Dai, Cheng-Qian, et al.
Publicado: (2020)

XingNaoJing, prescription of traditional Chinese medicine, prevents autophagy in experimental stroke by repressing p53-DRAM pathway
por: Wei, Gang, et al.
Publicado: (2015)

Tissue culture of Sophora tonkinensis Gapnep. and its quality evaluation
por: Kun-Hua, Wei, et al.
Publicado: (2013)

Diagnosis of Cardiac Amyloidosis Using a Radiomics Approach Applied to Late Gadolinium-Enhanced Cardiac Magnetic Resonance Images: A Retrospective, Multicohort, Diagnostic Study
por: Zhou, Xi Yang, et al.
Publicado: (2022)

Renal ectopic lipid deposition in rats with early-stage diabetic nephropathy evaluated by the MR mDixon-Quant technique: association with the expression of SREBP-1 and PPARα in renal tissue
por: Cheng, Jin-Mei, et al.
Publicado: (2023)

Thalidomide results in diminished ovarian reserve in reproductive age female IBD patients
por: Peng, Xiang, et al.
Publicado: (2017)

Successful treatment of an adult with Kasabach-Merritt syndrome using thalidomide, vincristine, and prednisone
por: Huang, Yue-Hua, et al.
Publicado: (2019)

Comparison of concurrent chemoradiotherapy followed by radical surgery and high-dose-rate intracavitary brachytherapy: a retrospective study of 240 patients with FIGO stage IIB cervical carcinoma
por: Wang, Ning, et al.
Publicado: (2014)

Clinical significance and molecular mechanism of angiotensin-converting enzyme 2 in hepatocellular carcinoma tissues
por: Huang, Wei-Jian, et al.
Publicado: (2021)

Methylprednisolone accelerate chest computed tomography absorption in COVID-19: A three-centered retrospective case control study from China
por: Lin, Lan, et al.
Publicado: (2022)

Pharmacotherapics Advice in Guidelines for COVID-19
por: Chen, Zhang-Ren, et al.
Publicado: (2020)

Retinoic Acid and Arsenic for Treating Acute Promyelocytic Leukemia
por: Zhou, Guang-Biao, et al.
Publicado: (2005)

HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia
por: Huang, Yan, et al.
Publicado: (2019)

Effects of Disease-Related Knowledge on Illness Perception and Psychological Status of Patients With COVID-19 in Hunan, China
por: Ye, Man, et al.
Publicado: (2021)

Measurement of Erythrocyte Lifespan Using a CO Breath Test in Patients with Thalassemia and the Impact of Treatment
por: Zhou, Yali, et al.
Publicado: (2023)

Three-dimensional computed tomography reconstruction diagnosed digestive tract perforation and acute peritonitis caused by Monopterus albus: A case report
por: Yang, Jin-Han, et al.
Publicado: (2023)

Resolution of an insidious and migratory Mycobacterium tuberculosis-associated secondary organizing pneumonia: a case report and literature review
por: Huang, Li-Li, et al.
Publicado: (2023)

Early Electronic Screen Exposure and Autistic-Like Behaviors among Preschoolers: The Mediating Role of Caregiver-Child Interaction, Sleep Duration and Outdoor Activities
por: Chen, Jing-Yi, et al.
Publicado: (2020)

Evaluation of the combination therapy of hydroxyurea and thalidomide in β-thalassemia
por: Ansari, Saqib H., et al.
Publicado: (2022)

2-(1,3-Dithian-2-ylidene)-1-phenylbutane-1,3-dione
por: Zhang, Lan-Cui, et al.
Publicado: (2008)

Inhibition of drug-metabolizing enzymes by Jingyin granules: implications of herb–drug interactions in antiviral therapy
por: Zhang, Feng, et al.
Publicado: (2021)

Efficacy of thalidomide therapy in pediatric Crohn’s disease with evidence of tuberculosis
por: Wang, Lin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_sptgtm7jdr8kqv5vs7m9a226qg