Mechanistic principles of an ultra-long bovine CDR reveal strategies for antibody design

Antibodies bind antigens via flexible loops called complementarity-determining regions (CDRs). These are usually 6-20 residues long. However, some bovine antibodies have ultra-long CDRs comprising more than 50 residues organized in a stalk and a disulfide-rich knob. The design features of this struc...

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Detalles Bibliográficos
Autores principales: Svilenov, Hristo L., Sacherl, Julia, Protzer, Ulrike, Zacharias, Martin, Buchner, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602281/
https://www.ncbi.nlm.nih.gov/pubmed/34795299
http://dx.doi.org/10.1038/s41467-021-27103-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602281/
https://www.ncbi.nlm.nih.gov/pubmed/34795299
http://dx.doi.org/10.1038/s41467-021-27103-z

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