Identifying regulators of parental imprinting by CRISPR/Cas9 screening in haploid human embryonic stem cells

In mammals, imprinted genes are regulated by differentially methylated regions (DMRs) that are inherited from germ cells, leading to monoallelic expression in accordance with parent-of-origin. Yet, it is largely unknown how imprinted DMRs are maintained in human embryos despite global DNA demethylat...

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Detalles Bibliográficos
Autores principales: Bar, Shiran, Vershkov, Dan, Keshet, Gal, Lezmi, Elyad, Meller, Naama, Yilmaz, Atilgan, Yanuka, Ofra, Nissim-Rafinia, Malka, Meshorer, Eran, Eldar-Geva, Talia, Benvenisty, Nissim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602306/
https://www.ncbi.nlm.nih.gov/pubmed/34795250
http://dx.doi.org/10.1038/s41467-021-26949-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602306/
https://www.ncbi.nlm.nih.gov/pubmed/34795250
http://dx.doi.org/10.1038/s41467-021-26949-7

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