Accurate and scalable variant calling from single cell DNA sequencing data with ProSolo

Accurate single cell mutational profiles can reveal genomic cell-to-cell heterogeneity. However, sequencing libraries suitable for genotyping require whole genome amplification, which introduces allelic bias and copy errors. The resulting data violates assumptions of variant callers developed for bu...

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Detalles Bibliográficos
Autores principales: Lähnemann, David, Köster, Johannes, Fischer, Ute, Borkhardt, Arndt, McHardy, Alice C., Schönhuth, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602313/
https://www.ncbi.nlm.nih.gov/pubmed/34795237
http://dx.doi.org/10.1038/s41467-021-26938-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602313/
https://www.ncbi.nlm.nih.gov/pubmed/34795237
http://dx.doi.org/10.1038/s41467-021-26938-w

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