HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

PARP1 and PARP2 produce poly(ADP-ribose) in response to DNA breaks. HPF1 regulates PARP1/2 catalytic output, most notably permitting serine modification with ADP-ribose. However, PARP1 is substantially more abundant in cells than HPF1, challenging whether HPF1 can pervasively modulate PARP1. Here, w...

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Detalles Bibliográficos
Autores principales: Langelier, Marie-France, Billur, Ramya, Sverzhinsky, Aleksandr, Black, Ben E., Pascal, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602370/
https://www.ncbi.nlm.nih.gov/pubmed/34795260
http://dx.doi.org/10.1038/s41467-021-27043-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602370/
https://www.ncbi.nlm.nih.gov/pubmed/34795260
http://dx.doi.org/10.1038/s41467-021-27043-8

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