Cargando…

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

PARP1 and PARP2 produce poly(ADP-ribose) in response to DNA breaks. HPF1 regulates PARP1/2 catalytic output, most notably permitting serine modification with ADP-ribose. However, PARP1 is substantially more abundant in cells than HPF1, challenging whether HPF1 can pervasively modulate PARP1. Here, w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Langelier, Marie-France, Billur, Ramya, Sverzhinsky, Aleksandr, Black, Ben E., Pascal, John M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602370/ https://www.ncbi.nlm.nih.gov/pubmed/34795260 http://dx.doi.org/10.1038/s41467-021-27043-8

Ejemplares similares

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
por: Suskiewicz, Marcin J., et al.
Publicado: (2020)

HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
por: Sun, Fa-Hui, et al.
Publicado: (2021)

Serine ADP-Ribosylation Depends on HPF1
por: Bonfiglio, Juan José, et al.
Publicado: (2017)

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity
por: Gibbs-Seymour, Ian, et al.
Publicado: (2016)

Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
por: Kurgina, Tatyana A., et al.
Publicado: (2021)

Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling
por: Karlberg, Tobias, et al.
Publicado: (2013)

The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
por: Hendriks, Ivo A., et al.
Publicado: (2021)

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
por: Bilokapic, Silvija, et al.
Publicado: (2020)

Slow Dissociation from the PARP1–HPF1 Complex Drives Inhibitor Potency
por: Stojanovic, Petra, et al.
Publicado: (2023)

Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1)
por: Zhang, Zhimin, et al.
Publicado: (2020)

Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy
por: Jannetti, Stephen A., et al.
Publicado: (2020)

The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors
por: De Soto, Joseph A., et al.
Publicado: (2006)

Poly(ADP-Ribose) Polymerase 1 (PARP-1) Regulates Ribosomal Biogenesis in Drosophila Nucleoli
por: Boamah, Ernest K., et al.
Publicado: (2012)

Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1
por: Zaniolo, Karine, et al.
Publicado: (2007)

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites
por: Altmeyer, Matthias, et al.
Publicado: (2009)

HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase
por: Rudolph, Johannes, et al.
Publicado: (2021)

Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice
por: Piskunova, Tatiana S., et al.
Publicado: (2008)

Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery
por: Noël, Georges, et al.
Publicado: (2003)

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
por: Caron, Marie-Christine, et al.
Publicado: (2019)

Poly(ADP-Ribose) Polymerase 1 (PARP1) Overexpression in Human Breast Cancer Stem Cells and Resistance to Olaparib
por: Gilabert, Marine, et al.
Publicado: (2014)

PARP1-produced poly-ADP-ribose causes the PARP12 translocation to stress granules and impairment of Golgi complex functions
por: Catara, Giuliana, et al.
Publicado: (2017)

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
por: Langelier, Marie-France, et al.
Publicado: (2014)

Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes
por: Agarwal, Ashok, et al.
Publicado: (2009)

Clinical Application of Poly(ADP-ribose) Polymerase (PARP) Inhibitors in Prostate Cancer
por: Inderjeeth, Andrisha-Jade, et al.
Publicado: (2022)

Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy
por: Harrision, Daniel, et al.
Publicado: (2020)

Gemcitabine Induces Poly (ADP-Ribose) Polymerase-1 (PARP-1) Degradation through Autophagy in Pancreatic Cancer
por: Wang, Yufeng, et al.
Publicado: (2014)

Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53
por: Shin, Hyeon-Jun, et al.
Publicado: (2015)

Poly(ADP‐ribose)‐mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function
por: Fischer, Jan M. F., et al.
Publicado: (2014)

Human mass balance study and metabolite profiling of (14)C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer
por: van Andel, Lotte, et al.
Publicado: (2017)

Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors
por: Faraoni, Isabella, et al.
Publicado: (2018)

Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1
por: Gaullier, Guillaume, et al.
Publicado: (2020)

Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53
por: Baumann, Cindy, et al.
Publicado: (2006)

ADP-ribose polymers localized on Ctcf–Parp1–Dnmt1 complex prevent methylation of Ctcf target sites
por: Zampieri, Michele, et al.
Publicado: (2011)

Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease
por: Salech, Felipe, et al.
Publicado: (2020)

Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylation
por: Li, Fangfei, et al.
Publicado: (2022)

Poly(ADP-ribose) Polyremase-1 (PARP-1) Inhibition: A Promising Therapeutic Strategy for ETS-Expressing Tumours
por: Legrand, Arnaud J., et al.
Publicado: (2023)

Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib
por: Gravells, Polly, et al.
Publicado: (2018)

Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1’-phosphatase
por: Webb, Thomas E., et al.
Publicado: (2020)

New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage
por: Gu, Zongying, et al.
Publicado: (2019)

HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation
por: Kumamoto, Soichiro, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hhdmh41ie2eiqort7fr3jjin8t