VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes

Chronic non-healing wounds, frequently caused by diabetes, lead to lower quality of life, infection, and amputation. These wounds have limited treatment options. We have previously engineered growth factors to bind to exposed extracellular matrix (ECM) in the wound environment using the heparin-bind...

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Detalles Bibliográficos
Autores principales: White, Michael J. V., Briquez, Priscilla S., White, David A. V., Hubbell, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602425/
https://www.ncbi.nlm.nih.gov/pubmed/34795305
http://dx.doi.org/10.1038/s41536-021-00189-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602425/
https://www.ncbi.nlm.nih.gov/pubmed/34795305
http://dx.doi.org/10.1038/s41536-021-00189-1

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