Phosphorylation activates the yeast small heat shock protein Hsp26 by weakening domain contacts in the oligomer ensemble

Hsp26 is a small heat shock protein (sHsp) from S. cerevisiae. Its chaperone activity is activated by oligomer dissociation at heat shock temperatures. Hsp26 contains 9 phosphorylation sites in different structural elements. Our analysis of phospho-mimetic mutations shows that phosphorylation activa...

Descripción completa

Detalles Bibliográficos
Autores principales: Mühlhofer, Moritz, Peters, Carsten, Kriehuber, Thomas, Kreuzeder, Marina, Kazman, Pamina, Rodina, Natalia, Reif, Bernd, Haslbeck, Martin, Weinkauf, Sevil, Buchner, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602628/
https://www.ncbi.nlm.nih.gov/pubmed/34795272
http://dx.doi.org/10.1038/s41467-021-27036-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602628/
https://www.ncbi.nlm.nih.gov/pubmed/34795272
http://dx.doi.org/10.1038/s41467-021-27036-7

Ejemplares similares