Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

The V3 loop of the HIV-1 envelope (Env) protein elicits a vigorous, but largely non-neutralizing antibody response directed to the V3-crown, whereas rare broadly neutralizing antibodies (bnAbs) target the V3-base. Challenging this view, we present V3-crown directed broadly neutralizing Designed Anky...

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Detalles Bibliográficos
Autores principales: Friedrich, Nikolas, Stiegeler, Emanuel, Glögl, Matthias, Lemmin, Thomas, Hansen, Simon, Kadelka, Claus, Wu, Yufan, Ernst, Patrick, Maliqi, Liridona, Foulkes, Caio, Morin, Mylène, Eroglu, Mustafa, Liechti, Thomas, Ivan, Branislav, Reinberg, Thomas, Schaefer, Jonas V., Karakus, Umut, Ursprung, Stephan, Mann, Axel, Rusert, Peter, Kouyos, Roger D., Robinson, John A., Günthard, Huldrych F., Plückthun, Andreas, Trkola, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602657/
https://www.ncbi.nlm.nih.gov/pubmed/34795280
http://dx.doi.org/10.1038/s41467-021-27075-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602657/
https://www.ncbi.nlm.nih.gov/pubmed/34795280
http://dx.doi.org/10.1038/s41467-021-27075-0

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