A somatic proteoglycan controls Notch-directed germ cell fate

Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, con...

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Autores principales: Gopal, Sandeep, Amran, Aqilah, Elton, Andre, Ng, Leelee, Pocock, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602670/
https://www.ncbi.nlm.nih.gov/pubmed/34795288
http://dx.doi.org/10.1038/s41467-021-27039-4
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author Gopal, Sandeep
Amran, Aqilah
Elton, Andre
Ng, Leelee
Pocock, Roger
author_facet Gopal, Sandeep
Amran, Aqilah
Elton, Andre
Ng, Leelee
Pocock, Roger
author_sort Gopal, Sandeep
collection PubMed
description Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions.
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spelling pubmed-86026702021-12-03 A somatic proteoglycan controls Notch-directed germ cell fate Gopal, Sandeep Amran, Aqilah Elton, Andre Ng, Leelee Pocock, Roger Nat Commun Article Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions. Nature Publishing Group UK 2021-11-18 /pmc/articles/PMC8602670/ /pubmed/34795288 http://dx.doi.org/10.1038/s41467-021-27039-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gopal, Sandeep
Amran, Aqilah
Elton, Andre
Ng, Leelee
Pocock, Roger
A somatic proteoglycan controls Notch-directed germ cell fate
title A somatic proteoglycan controls Notch-directed germ cell fate
title_full A somatic proteoglycan controls Notch-directed germ cell fate
title_fullStr A somatic proteoglycan controls Notch-directed germ cell fate
title_full_unstemmed A somatic proteoglycan controls Notch-directed germ cell fate
title_short A somatic proteoglycan controls Notch-directed germ cell fate
title_sort somatic proteoglycan controls notch-directed germ cell fate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602670/
https://www.ncbi.nlm.nih.gov/pubmed/34795288
http://dx.doi.org/10.1038/s41467-021-27039-4
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