Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors

Neoantigen discovery in pediatric brain tumors is hampered by their low mutational burden and scant tissue availability. Here we develop a proteogenomic approach combining tumor DNA/RNA sequencing and mass spectrometry proteomics to identify tumor-restricted (neoantigen) peptides arising from multip...

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Detalles Bibliográficos
Autores principales: Rivero-Hinojosa, Samuel, Grant, Melanie, Panigrahi, Aswini, Zhang, Huizhen, Caisova, Veronika, Bollard, Catherine M., Rood, Brian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602676/
https://www.ncbi.nlm.nih.gov/pubmed/34795224
http://dx.doi.org/10.1038/s41467-021-26936-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602676/
https://www.ncbi.nlm.nih.gov/pubmed/34795224
http://dx.doi.org/10.1038/s41467-021-26936-y

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