MeCP2 Epigenetic Silencing of Oprm1 Gene in Primary Sensory Neurons Under Neuropathic Pain Conditions

Opioids are the last option for the pharmacological treatment of neuropathic pain, but their antinociceptive effects are limited. Decreased mu opioid receptor (MOR) expression in the peripheral nervous system may contribute to this. Here, we showed that nerve injury induced hypermethylation of the O...

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Detalles Bibliográficos
Autores principales: Sun, Na, Yu, Lina, Gao, Yibo, Ma, Longfei, Ren, Jinxuan, Liu, Ying, Gao, Dave Schwinn, Xie, Chen, Wu, Ying, Wang, Lieju, Hong, Juncong, Yan, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602696/
https://www.ncbi.nlm.nih.gov/pubmed/34803588
http://dx.doi.org/10.3389/fnins.2021.743207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602696/
https://www.ncbi.nlm.nih.gov/pubmed/34803588
http://dx.doi.org/10.3389/fnins.2021.743207

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