Sinomenine Relieves Airway Remodeling By Inhibiting Epithelial-Mesenchymal Transition Through Downregulating TGF-β1 and Smad3 Expression In Vitro and In Vivo

Airway remodeling is associated with dysregulation of epithelial-mesenchymal transition (EMT) in patients with asthma. Sinomenine (Sin) is an effective, biologically active alkaloid that has been reported to suppress airway remodeling in mice with asthma. However, the molecular mechanisms behind thi...

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Detalles Bibliográficos
Autores principales: He, Hongjuan, Cao, Lihua, Wang, Zheng, Wang, Zhenzhen, Miao, Jinxin, Li, Xiu-Min, Miao, Mingsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602849/
https://www.ncbi.nlm.nih.gov/pubmed/34804018
http://dx.doi.org/10.3389/fimmu.2021.736479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602849/
https://www.ncbi.nlm.nih.gov/pubmed/34804018
http://dx.doi.org/10.3389/fimmu.2021.736479

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