A Novel Combined Conjugate Therapeutic Cancer Vaccine, Recombinant EGF-CRM197, in Patients With Advanced Solid Tumors: A Phase I Clinical Study

INTRODUCTION: The therapeutic cancer vaccine recombinant Epidermal Growth Factor (EGF)-CRM197 is a novel combined conjugate EGF with CRM197 as a carrier protein. Immunization with the EGF-CRM197 vaccine can induce high levels of neutralizing anti-EGF antibodies that inhibit EGF/EGFR signaling and th...

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Detalles Bibliográficos
Autores principales: Xiong, An-Wen, Fang, Jue-Min, Ren, Sheng-Xiang, Li, Wei, Wang, Jing, Zhao, Yu, Chen, Guo-You, Xu, Qing, Zhou, Cai-Cun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602890/
https://www.ncbi.nlm.nih.gov/pubmed/34804932
http://dx.doi.org/10.3389/fonc.2021.745699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602890/
https://www.ncbi.nlm.nih.gov/pubmed/34804932
http://dx.doi.org/10.3389/fonc.2021.745699

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