The Effect of Metformin on the Proliferation, Apoptosis and CD133 mRNA Expression of Colon Cancer Stem Cells by Upregulation of miR 342-3p

OBJECTIVE: To explore whether metformin (MET) can affect the biological behaviour and CD133 mRNA expression of CD133(+) colon cancer stem cells (CCSCs) through miR-342-3p. METHODS: The direct immunomagnetic bead method was used to select CD133(+) CCSCs from the SW480 and HCT116 cell lines, and miRNA...

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Detalles Bibliográficos
Autores principales: Zhang, Yaqin, Chen, Ruofei, Deng, Lili, Shuai, Zongwen, Chen, Mingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602950/
https://www.ncbi.nlm.nih.gov/pubmed/34815662
http://dx.doi.org/10.2147/DDDT.S336490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602950/
https://www.ncbi.nlm.nih.gov/pubmed/34815662
http://dx.doi.org/10.2147/DDDT.S336490

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