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The Effect of Metformin on the Proliferation, Apoptosis and CD133 mRNA Expression of Colon Cancer Stem Cells by Upregulation of miR 342-3p
OBJECTIVE: To explore whether metformin (MET) can affect the biological behaviour and CD133 mRNA expression of CD133(+) colon cancer stem cells (CCSCs) through miR-342-3p. METHODS: The direct immunomagnetic bead method was used to select CD133(+) CCSCs from the SW480 and HCT116 cell lines, and miRNA...
Autores principales: | Zhang, Yaqin, Chen, Ruofei, Deng, Lili, Shuai, Zongwen, Chen, Mingwei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602950/ https://www.ncbi.nlm.nih.gov/pubmed/34815662 http://dx.doi.org/10.2147/DDDT.S336490 |
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