Orientation of α-Synuclein at Negatively Charged Lipid Vesicles: Linear Dichroism Reveals Time-Dependent Changes in Helix Binding Mode

[Image: see text] The neuronal protein α-synuclein, linked to Parkinson’s disease, binds to negatively charged vesicles adopting a partial α-helix structure, but helix arrangement at the vesicle surface is not fully understood. Using linear dichroism spectroscopy (LD), we study the interaction of mo...

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Detalles Bibliográficos
Autores principales: Rocha, Sandra, Kumar, Ranjeet, Nordén, Bengt, Wittung-Stafshede, Pernilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603351/
https://www.ncbi.nlm.nih.gov/pubmed/34748321
http://dx.doi.org/10.1021/jacs.1c05344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603351/
https://www.ncbi.nlm.nih.gov/pubmed/34748321
http://dx.doi.org/10.1021/jacs.1c05344

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