Cargando…

Cystatin C Plays a Sex-Dependent Detrimental Role in Experimental Autoimmune Encephalomyelitis

The cysteine protease inhibitor Cystatin C (CST3) is highly expressed in the brains of multiple sclerosis (MS) patients and C57BL/6J mice with experimental autoimmune encephalomyelitis (EAE; a model of MS), but its roles in the diseases are unknown. Here, we show that CST3 plays a detrimental functi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoghooghi, Vahid, Palmer, Alexandra L., Frederick, Ariana, Jiang, Yulan, Merkens, Jessica E., Balakrishnan, Anjali, Finlay, Trisha M., Grubb, Anders, Levy, Efrat, Gordon, Paul, Jirik, Frank R., Nguyen, Minh Dang, Schuurmans, Carol, Visser, Frank, Dunn, Shannon E., Ousman, Shalina S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603395/ https://www.ncbi.nlm.nih.gov/pubmed/33027652 http://dx.doi.org/10.1016/j.celrep.2020.108236

Ejemplares similares

Presence and activation of pro-inflammatory macrophages are associated with CRYAB expression in vitro and after peripheral nerve injury
por: Lim, Erin-Mai F., et al.
Publicado: (2021)

Chaperone Proteins in the Central Nervous System and Peripheral Nervous System after Nerve Injury
por: Ousman, Shalina S., et al.
Publicado: (2017)

Cystatin C is Indispensable for Evaluation of Kidney Disease
por: Grubb, Anders
Publicado: (2017)

Cystatin C-Properties and use as diagnostic marker
por: Grubb, Anders O.
Publicado: (2001)

Cystatin C in Alzheimer's disease
por: Kaur, Gurjinder, et al.
Publicado: (2012)

Immune surveillance in the central nervous system
por: Ousman, Shalina S, et al.
Publicado: (2012)

A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis
por: Gupta, Angela S., et al.
Publicado: (2019)

Muscle mass, creatinine, cystatin C and selective glomerular hypofiltration syndromes
por: Malmgren, Linnea, et al.
Publicado: (2023)

Production of Cystatin C Wild Type and Stabilized Mutants
por: Pollak, Joanna, et al.
Publicado: (2010)

Astrocytes and Aging
por: Palmer, Alexandra L., et al.
Publicado: (2018)

The immune response and aging in chronic inflammatory demyelinating polyradiculoneuropathy
por: Hagen, Kathleen M., et al.
Publicado: (2021)

The Neuroimmunology of Guillain-Barré Syndrome and the Potential Role of an Aging Immune System
por: Hagen, Kathleen M., et al.
Publicado: (2021)

Stabilization, Characterization, and Selective Removal of Cystatin C Amyloid Oligomers
por: Östner, Gustav, et al.
Publicado: (2013)

The domain swapping of human cystatin C induced by synchrotron radiation
por: Taube, Michal, et al.
Publicado: (2019)

Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers
por: Chrabąszczewska, Magdalena, et al.
Publicado: (2020)

Induction of Autophagy by Cystatin C: A Mechanism That Protects Murine Primary Cortical Neurons and Neuronal Cell Lines
por: Tizon, Belen, et al.
Publicado: (2010)

Improved estimation of glomerular filtration rate (GFR) by comparison of eGFR(cystatin C) and eGFR(creatinine)
por: Grubb, Anders, et al.
Publicado: (2012)

Cystatin C, a marker for successful aging and glomerular filtration rate, is not influenced by inflammation
por: Grubb, Anders, et al.
Publicado: (2011)

Neuroprotection mediated by cystatin C-loaded extracellular vesicles
por: Pérez-González, Rocío, et al.
Publicado: (2019)

Goodbye or Identify: Detrimental Effects of Downsizing on Identification and Survivor Performance
por: van Dick, Rolf, et al.
Publicado: (2016)

Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis
por: Li, Wei, et al.
Publicado: (2016)

Beneficial and detrimental effects of schema incongruence on memory for contextual events
por: Frank, Darya, et al.
Publicado: (2018)

Non-invasive estimation of glomerular filtration rate (GFR). The Lund model: Simultaneous use of cystatin C- and creatinine-based GFR-prediction equations, clinical data and an internal quality check
por: Grubb, Anders
Publicado: (2010)

Two new types of assays to determine protein concentrations in biological fluids using mass spectrometry of intact proteins with cystatin C in spinal fluid as an example
por: Tyrefors, Niklas, et al.
Publicado: (2014)

The Emerging Role of Extracellular Vesicles in the Glioma Microenvironment: Biogenesis and Clinical Relevance
por: Balakrishnan, Anjali, et al.
Publicado: (2020)

Myalgic Encephalomyelitis (ME) or What? An Operational Definition
por: Twisk, Frank
Publicado: (2018)

Myalgic Encephalomyelitis or What? The International Consensus Criteria
por: Twisk, Frank
Publicado: (2018)

Potential relationship between eGFR(cystatin C)/eGFR(creatinine)‐ratio and glomerular basement membrane thickness in diabetic kidney disease
por: Öberg, Carl M., et al.
Publicado: (2021)

Large difference but high correlation between creatinine and cystatin C estimated glomerular filtration rate in Mesoamerican sugarcane cutters
por: Andersson, Axel, et al.
Publicado: (2022)

Reducing Detrimental Defects for High‐Performance Metal Halide Perovskite Solar Cells
por: Ono, Luis K., et al.
Publicado: (2020)

Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development
por: Bäcklund, Alexandra, et al.
Publicado: (2011)

The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation
por: Malmgren, Linnea, et al.
Publicado: (2022)

Age‐related changes to macrophages are detrimental to fracture healing in mice
por: Clark, Daniel, et al.
Publicado: (2020)

Peroxisome proliferator–activated receptor (PPAR)α expression in T cells mediates gender differences in development of T cell–mediated autoimmunity
por: Dunn, Shannon E., et al.
Publicado: (2007)

Peroxisome proliferator–activated receptor (PPAR)α expression in T cells mediates gender differences in development of T cell–mediated autoimmunity
por: Dunn, Shannon E., et al.
Publicado: (2007)

Correction: Peroxisome proliferator–activated receptor (PPAR)α expression in T cells mediates gender differences in development of T cell–mediated autoimmunity
por: Dunn, Shannon E., et al.
Publicado: (2018)

Cystatins in Immune System
por: Magister, Špela, et al.
Publicado: (2012)

Cystatins in Health and Diseases
por: Shah, Aaliya, et al.
Publicado: (2008)

PROTEINASE INHIBITORS | Cystatins
por: Pemberton, P.A.
Publicado: (2006)

Cystatin C as a Marker for Glomerular Filtration Rate in Critically Ill Neonates and Children: Validation Against Iohexol Plasma Clearance
por: Smeets, Nori J.L., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m6qcf2n923prpe7rbtli71ju5b