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Mendelian randomisation with coarsened exposures

A key assumption in Mendelian randomisation is that the relationship between the genetic instruments and the outcome is fully mediated by the exposure, known as the exclusion restriction assumption. However, in epidemiological studies, the exposure is often a coarsened approximation to some latent c...

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Detalles Bibliográficos
Autores principales: Tudball, Matthew J., Bowden, Jack, Hughes, Rachael A., Ly, Amanda, Munafò, Marcus R., Tilling, Kate, Zhao, Qingyuan, Davey Smith, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603937/
https://www.ncbi.nlm.nih.gov/pubmed/33527565
http://dx.doi.org/10.1002/gepi.22376