A Potential Treatment of Congenital Sodium Diarrhea in Patients With Activating GUCY2C Mutations

INTRODUCTION: Gain-of-function mutations in guanylyl cyclase C (GCC) result in persistent diarrhea with perinatal onset. We investigated a specific GCC inhibitor, SSP2518, for its potential to treat this disorder. METHODS: We investigated the effect of SSP2518 on GCC-mediated intracellular cyclic gu...

Descripción completa

Detalles Bibliográficos
Autores principales: van Vugt, Anke H.M., Bijvelds, Marcel J.C., de Jonge, Hugo R., Meijsen, Kelly F., Restin, Tanja, Bryant, Manuel B., Ballauff, Antje, Koot, Bart, Müller, Thomas, Houwen, Roderick H.J., Janecke, Andreas R., Middendorp, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604003/
https://www.ncbi.nlm.nih.gov/pubmed/34797252
http://dx.doi.org/10.14309/ctg.0000000000000427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604003/
https://www.ncbi.nlm.nih.gov/pubmed/34797252
http://dx.doi.org/10.14309/ctg.0000000000000427

Ejemplares similares