Evaluation of moxifloxacin in canine and non‐human primate telemetry assays: Comparison of QTc interval prolongation by timepoint and concentration‐QTc analysis

The in vivo correct QT (QTc) assay is used by the pharmaceutical industry to characterize the potential for delayed ventricular repolarization and is a core safety assay mentioned in International Conference on Harmonization (ICH) S7B guideline. The typical telemetry study involves a dose‐response a...

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Detalles Bibliográficos
Autores principales: Chui, Ray W., Baublits, Joel, Chandra, Fiona A., Jones, Zack W., Engwall, Michael J., Vargas, Hugo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604216/
https://www.ncbi.nlm.nih.gov/pubmed/34173339
http://dx.doi.org/10.1111/cts.13103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604216/
https://www.ncbi.nlm.nih.gov/pubmed/34173339
http://dx.doi.org/10.1111/cts.13103

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