Pharmacokinetically guided dosing of oral sorafenib in pediatric hepatocellular carcinoma: A simulation study

Sorafenib improves outcomes in adult hepatocellular carcinoma; however, hand foot skin reaction (HFSR) is a dose limiting toxicity of sorafenib that limits its use. HFSR has been associated with sorafenib systemic exposure. The objective of this study was to use modeling and simulation to determine...

Descripción completa

Detalles Bibliográficos
Autores principales: Panetta, John C., Campagne, Olivia, Gartrell, Jessica, Furman, Wayne, Stewart, Clinton F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604221/
https://www.ncbi.nlm.nih.gov/pubmed/34060723
http://dx.doi.org/10.1111/cts.13069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604221/
https://www.ncbi.nlm.nih.gov/pubmed/34060723
http://dx.doi.org/10.1111/cts.13069

Ejemplares similares