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Pharmacokinetically guided dosing of oral sorafenib in pediatric hepatocellular carcinoma: A simulation study

Sorafenib improves outcomes in adult hepatocellular carcinoma; however, hand foot skin reaction (HFSR) is a dose limiting toxicity of sorafenib that limits its use. HFSR has been associated with sorafenib systemic exposure. The objective of this study was to use modeling and simulation to determine...

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Detalles Bibliográficos
Autores principales:	Panetta, John C., Campagne, Olivia, Gartrell, Jessica, Furman, Wayne, Stewart, Clinton F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604221/ https://www.ncbi.nlm.nih.gov/pubmed/34060723 http://dx.doi.org/10.1111/cts.13069

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