Large variability in plasma efavirenz concentration in Papua New Guinea HIV/AIDS patients associated with high frequency of CYP2B6 516T allele

Papua New Guinea (PNG) has a high HIV/AIDS prevalence and very high frequency of the CYP2B6 c.516G>T (rs3745274) variant. We have conducted the first investigation of the impact of c.516G>T and patient demographics on plasma efavirenz (EFV) and 8‐hydroxyefavirenz (8OH‐EFV) concentrations, meta...

Descripción completa

Detalles Bibliográficos
Autores principales: Bordin Andriguetti, Natália, Van Schalkwyk, Helena Katherina, Barratt, Daniel Thomas, Tucci, Joseph, Pumuye, Paul, Somogyi, Andrew Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604234/
https://www.ncbi.nlm.nih.gov/pubmed/34415664
http://dx.doi.org/10.1111/cts.13120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604234/
https://www.ncbi.nlm.nih.gov/pubmed/34415664
http://dx.doi.org/10.1111/cts.13120

Ejemplares similares