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Large variability in plasma efavirenz concentration in Papua New Guinea HIV/AIDS patients associated with high frequency of CYP2B6 516T allele

Papua New Guinea (PNG) has a high HIV/AIDS prevalence and very high frequency of the CYP2B6 c.516G>T (rs3745274) variant. We have conducted the first investigation of the impact of c.516G>T and patient demographics on plasma efavirenz (EFV) and 8‐hydroxyefavirenz (8OH‐EFV) concentrations, meta...

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Detalles Bibliográficos
Autores principales:	Bordin Andriguetti, Natália, Van Schalkwyk, Helena Katherina, Barratt, Daniel Thomas, Tucci, Joseph, Pumuye, Paul, Somogyi, Andrew Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604234/ https://www.ncbi.nlm.nih.gov/pubmed/34415664 http://dx.doi.org/10.1111/cts.13120

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