Amino acid residues at core protein dimer-dimer interface modulate multiple steps of hepatitis B virus replication and HBeAg biogenesis

The core protein (Cp) of hepatitis B virus (HBV) assembles pregenomic RNA (pgRNA) and viral DNA polymerase to form nucleocapsids where the reverse transcriptional viral DNA replication takes place. Core protein allosteric modulators (CpAMs) inhibit HBV replication by binding to a hydrophobic “HAP” p...

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Detalles Bibliográficos
Autores principales: Liu, Hui, Cheng, Junjun, Viswanathan, Usha, Chang, Jinhong, Lu, Fengmin, Guo, Ju-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604296/
https://www.ncbi.nlm.nih.gov/pubmed/34752483
http://dx.doi.org/10.1371/journal.ppat.1010057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604296/
https://www.ncbi.nlm.nih.gov/pubmed/34752483
http://dx.doi.org/10.1371/journal.ppat.1010057

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