Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores

Complement proteins can form membrane attack complex (MAC) pores that directly kill Gram-negative bacteria. MAC pores assemble by stepwise binding of C5b, C6, C7, C8 and finally C9, which can polymerize into a transmembrane ring of up to 18 C9 monomers. It is still unclear if the assembly of a polym...

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Detalles Bibliográficos
Autores principales: Doorduijn, Dennis J., Heesterbeek, Dani A. C., Ruyken, Maartje, de Haas, Carla J. C., Stapels, Daphne A. C., Aerts, Piet C., Rooijakkers, Suzan H. M., Bardoel, Bart W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604303/
https://www.ncbi.nlm.nih.gov/pubmed/34752492
http://dx.doi.org/10.1371/journal.ppat.1010051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604303/
https://www.ncbi.nlm.nih.gov/pubmed/34752492
http://dx.doi.org/10.1371/journal.ppat.1010051

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