Cargando…
Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores
Complement proteins can form membrane attack complex (MAC) pores that directly kill Gram-negative bacteria. MAC pores assemble by stepwise binding of C5b, C6, C7, C8 and finally C9, which can polymerize into a transmembrane ring of up to 18 C9 monomers. It is still unclear if the assembly of a polym...
Autores principales: | Doorduijn, Dennis J., Heesterbeek, Dani A. C., Ruyken, Maartje, de Haas, Carla J. C., Stapels, Daphne A. C., Aerts, Piet C., Rooijakkers, Suzan H. M., Bardoel, Bart W. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604303/ https://www.ncbi.nlm.nih.gov/pubmed/34752492 http://dx.doi.org/10.1371/journal.ppat.1010051 |
Ejemplares similares
-
Correction: Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores
por: Doorduijn, Dennis J., et al.
Publicado: (2022) -
Bacterial killing by complement requires direct anchoring of membrane attack complex precursor C5b-7
por: Doorduijn, Dennis J., et al.
Publicado: (2020) -
Bacterial killing by complement requires membrane attack complex formation via surface‐bound C5 convertases
por: Heesterbeek, Dani AC, et al.
Publicado: (2019) -
Artificial surface labelling of Escherichia coli with StrepTagII antigen to study how monoclonal antibodies drive complement-mediated killing
por: Muts, Remy M., et al.
Publicado: (2023) -
Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5
por: Doorduijn, Dennis J, et al.
Publicado: (2022)