Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance

Very high risk neuroblastoma is characterised by increased MAPK signalling, and targeting MAPK signalling is a promising therapeutic strategy. We used a deeply characterised panel of neuroblastoma cell lines and found that the sensitivity to MEK inhibitors varied drastically between these cell lines...

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Detalles Bibliográficos
Autores principales: Dorel, Mathurin, Klinger, Bertram, Mari, Tommaso, Toedling, Joern, Blanc, Eric, Messerschmidt, Clemens, Nadler-Holly, Michal, Ziehm, Matthias, Sieber, Anja, Hertwig, Falk, Beule, Dieter, Eggert, Angelika, Schulte, Johannes H., Selbach, Matthias, Blüthgen, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604339/
https://www.ncbi.nlm.nih.gov/pubmed/34735429
http://dx.doi.org/10.1371/journal.pcbi.1009515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604339/
https://www.ncbi.nlm.nih.gov/pubmed/34735429
http://dx.doi.org/10.1371/journal.pcbi.1009515

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