Physics-based modeling provides predictive understanding of selectively promiscuous substrate binding by Hsp70 chaperones

To help cells cope with protein misfolding and aggregation, Hsp70 molecular chaperones selectively bind a variety of sequences (“selective promiscuity”). Statistical analyses from substrate-derived peptide arrays reveal that DnaK, the E. coli Hsp70, binds to sequences containing three to five branch...

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Detalles Bibliográficos
Autores principales: Nordquist, Erik B., English, Charles A., Clerico, Eugenia M., Sherman, Woody, Gierasch, Lila M., Chen, Jianhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604352/
https://www.ncbi.nlm.nih.gov/pubmed/34735438
http://dx.doi.org/10.1371/journal.pcbi.1009567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604352/
https://www.ncbi.nlm.nih.gov/pubmed/34735438
http://dx.doi.org/10.1371/journal.pcbi.1009567

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