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Physics-based modeling provides predictive understanding of selectively promiscuous substrate binding by Hsp70 chaperones
To help cells cope with protein misfolding and aggregation, Hsp70 molecular chaperones selectively bind a variety of sequences (“selective promiscuity”). Statistical analyses from substrate-derived peptide arrays reveal that DnaK, the E. coli Hsp70, binds to sequences containing three to five branch...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604352/ https://www.ncbi.nlm.nih.gov/pubmed/34735438 http://dx.doi.org/10.1371/journal.pcbi.1009567 |