Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding

Kinesins are regulated in space and time to ensure activation only in the presence of cargo. Kinesin-binding protein (KIFBP), which is mutated in Goldberg-Shprintzen syndrome, binds to and inhibits the catalytic motor heads of 8 of 45 kinesin superfamily members, but the mechanism remains poorly def...

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Detalles Bibliográficos
Autores principales: Solon, April L., Tan, Zhenyu, Schutt, Katherine L., Jepsen, Lauren, Haynes, Sarah E., Nesvizhskii, Alexey I., Sept, David, Stumpff, Jason, Ohi, Ryoma, Cianfrocco, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604404/
https://www.ncbi.nlm.nih.gov/pubmed/34797717
http://dx.doi.org/10.1126/sciadv.abj9812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604404/
https://www.ncbi.nlm.nih.gov/pubmed/34797717
http://dx.doi.org/10.1126/sciadv.abj9812

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