R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage

How DNA damage leads to chronic inflammation and tissue degeneration with aging remains to be fully resolved. Here, we show that DNA damage leads to cellular senescence, fibrosis, loss-of-tissue architecture, and chronic pancreatitis in mice with an inborn defect in the excision repair cross complem...

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Detalles Bibliográficos
Autores principales: Chatzidoukaki, Ourania, Stratigi, Kalliopi, Goulielmaki, Evi, Niotis, George, Akalestou-Clocher, Alexia, Gkirtzimanaki, Katerina, Zafeiropoulos, Alexandros, Altmüller, Janine, Topalis, Pantelis, Garinis, George A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604417/
https://www.ncbi.nlm.nih.gov/pubmed/34797720
http://dx.doi.org/10.1126/sciadv.abj5769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604417/
https://www.ncbi.nlm.nih.gov/pubmed/34797720
http://dx.doi.org/10.1126/sciadv.abj5769

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