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Nanoparticles from Gantrez-based conjugates for the oral delivery of camptothecin

Camptothecin (CPT) exhibits a number of challenges for its oral administration, including a low aqueous solubility, a lactone ring susceptible to hydrolysis, and an affinity to the intestinal P-gp. The aim of this work was to evaluate nanoparticles from Gantrez-based conjugates as carriers for the o...

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Detalles Bibliográficos
Autores principales: Huarte, Judit, Espuelas, Socorro, Martínez-Oharriz, Cristina, Irache, Juan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604667/
https://www.ncbi.nlm.nih.gov/pubmed/34825166
http://dx.doi.org/10.1016/j.ijpx.2021.100104