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The MttB superfamily member MtyB from the human gut symbiont Eubacterium limosum is a cobalamin-dependent γ-butyrobetaine methyltransferase

The production of trimethylamine (TMA) from quaternary amines such as l-carnitine or γ-butyrobetaine (4-(trimethylammonio)butanoate) by gut microbial enzymes has been linked to heart disease. This has led to interest in enzymes of the gut microbiome that might ameliorate net TMA production, such as...

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Detalles Bibliográficos
Autores principales: Ellenbogen, Jared B., Jiang, Ruisheng, Kountz, Duncan J., Zhang, Liwen, Krzycki, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604678/
https://www.ncbi.nlm.nih.gov/pubmed/34688665
http://dx.doi.org/10.1016/j.jbc.2021.101327