The protease-sensitive N-terminal polybasic region of prion protein modulates its conversion to the pathogenic prion conformer

Conversion of normal prion protein (PrP(C)) to the pathogenic PrP(Sc) conformer is central to prion diseases such as Creutzfeldt–Jakob disease and scrapie; however, the detailed mechanism of this conversion remains obscure. To investigate how the N-terminal polybasic region of PrP (NPR) influences t...

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Detalles Bibliográficos
Autores principales: Zhang, Xiangyi, Pan, Yi-Hsuan, Chen, Ying, Pan, Chenhua, Ma, Ji, Yuan, Chonggang, Yu, Guohua, Ma, Jiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604679/
https://www.ncbi.nlm.nih.gov/pubmed/34710372
http://dx.doi.org/10.1016/j.jbc.2021.101344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604679/
https://www.ncbi.nlm.nih.gov/pubmed/34710372
http://dx.doi.org/10.1016/j.jbc.2021.101344

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