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The protease-sensitive N-terminal polybasic region of prion protein modulates its conversion to the pathogenic prion conformer
Conversion of normal prion protein (PrP(C)) to the pathogenic PrP(Sc) conformer is central to prion diseases such as Creutzfeldt–Jakob disease and scrapie; however, the detailed mechanism of this conversion remains obscure. To investigate how the N-terminal polybasic region of PrP (NPR) influences t...
Autores principales: | Zhang, Xiangyi, Pan, Yi-Hsuan, Chen, Ying, Pan, Chenhua, Ma, Ji, Yuan, Chonggang, Yu, Guohua, Ma, Jiyan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604679/ https://www.ncbi.nlm.nih.gov/pubmed/34710372 http://dx.doi.org/10.1016/j.jbc.2021.101344 |
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