High doses of dexamethasone induce endoplasmic reticulum stress-mediated apoptosis by promoting calcium ion influx-dependent CHOP expression in osteoblasts

BACKGROUND: The long-term use of dexamethasone (Dex), a well-known immunosuppressant, leads to an imbalance in bone metabolism and rapid decline of bone mineral density due to apoptosis of osteoblasts. The molecular mechanisms by which Dex induces osteoblast apoptosis remain unclear. MATERIALS AND M...

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Detalles Bibliográficos
Autores principales: Guo, Yunshan, Hao, Dingjun, Hu, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604853/
https://www.ncbi.nlm.nih.gov/pubmed/34698990
http://dx.doi.org/10.1007/s11033-021-06806-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604853/
https://www.ncbi.nlm.nih.gov/pubmed/34698990
http://dx.doi.org/10.1007/s11033-021-06806-y

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