Fibroblast transition to an endothelial “trans” state improves cell reprogramming efficiency

Fibroblast reprogramming offers the potential for myocardial regeneration via in situ cell transdifferentiation. We explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming efficiency. Rat cardiac endothelial cells and fibroblasts were treated with Gata4, Mef2c, and...

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Detalles Bibliográficos
Autores principales: Mathison, Megumi, Sanagasetti, Deepthi, Singh, Vivek P., Pugazenthi, Aarthi, Pinnamaneni, Jaya Pratap, Ryan, Christopher T., Yang, Jianchang, Rosengart, Todd K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604927/
https://www.ncbi.nlm.nih.gov/pubmed/34799643
http://dx.doi.org/10.1038/s41598-021-02056-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604927/
https://www.ncbi.nlm.nih.gov/pubmed/34799643
http://dx.doi.org/10.1038/s41598-021-02056-x

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