Mechanistic and genetic basis of single-strand templated repair at Cas12a-induced DNA breaks in Chlamydomonas reinhardtii

Single-stranded oligodeoxynucleotides (ssODNs) are widely used as DNA repair templates in CRISPR/Cas precision genome editing. However, the underlying mechanisms of single-strand templated DNA repair (SSTR) are inadequately understood, constraining rational improvements to precision editing. Here we...

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Detalles Bibliográficos
Autores principales: Ferenczi, Aron, Chew, Yen Peng, Kroll, Erika, von Koppenfels, Charlotte, Hudson, Andrew, Molnar, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604939/
https://www.ncbi.nlm.nih.gov/pubmed/34799578
http://dx.doi.org/10.1038/s41467-021-27004-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604939/
https://www.ncbi.nlm.nih.gov/pubmed/34799578
http://dx.doi.org/10.1038/s41467-021-27004-1

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